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KMID : 1123920050190051349
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 5 p.1349 ~ p.1355
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Protective Effect of Rehmannia Radix Preparata Extract on the Cisplatin-induced Cytotoxicity of HEI-OC1 Cells via Scavenging of Free Radicals
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Yu Hyeon-Hee
Seo Se-Jeong
Kim Yeon-Hwa
Park Rae-Gil
So Hong-Seob
Jeon Byung-Hoon
Shin Mi-Kyoung
Jung Su-Young
Kim Ki-Young
You Yong-Ouk
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Abstract
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The steamed root of Rehmannia glutinosa has been used for treatment of inner ear diseases, such as tinnitus and hearing loss in traditional Oriental Medicine. In the present study, we investigated the effect of ethanol extract of steamed root R. glutinosa (SRG) on cisplatin cytotoxicity of HEI-OC1 auditory cells. In addition, to investigate the mechanism of SRG on cisplatin cytotoxicity, the effects of SRG on lipid peroxidation as well as scavenging activities against various free radicals were measured in cisplatin-treated cells. Treatment of SRG protected cells from cisplatin and reduced lipid peroxidation in a dose-dependent manner. Furthermore, SRG demonstrated significant scavenging activity against various free radicals, including superoxide radical, hydroxyl radical, hydrogen peroxide, and DPPH radical. These results indicate that SRG protects cisplatin-induced damages of HEI-OC1 cells through inhibition of lipid peroxidation and augmenting scavenging activities against free radials.
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KEYWORD
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Rehmannia glutinosa, HEI-OC1 cell, Cisplatin, Reactive oxygen species, Free radical
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